Biohacking

Evidence-based protocols for sleep, cognition, longevity, and metabolic health optimization.

The biohacking landscape is maturing from "bro-science" to precision medicine. We cut through the noise with protocols grounded in the GRADE evidence framework — every recommendation backed by peer-reviewed clinical data, not influencer claims.

Free Interactive Tool

Build Your Evidence-Based Stack

Stop guessing. Our Biohacking Stack Builder uses the GRADE evidence framework to recommend safety-screened supplements and devices based on your goals, budget, and health profile. Includes dosage, timing, mechanism, evidence tier, and monthly cost estimates.

Build My Stack →

Core Protocol Categories

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Sleep Architecture

Optimize slow-wave and REM sleep using Magnesium Glycinate, Tart Cherry, and Apigenin. The foundation of every high-performance protocol.

Tier 1 — Multiple RCTs

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Cognitive Enhancement

Boost acetylcholine and modulate cortisol with Alpha-GPC, L-Theanine/Caffeine stacks, Ashwagandha (KSM-66), and Lion's Mane mushroom.

Tier 1-2 — RCTs + Mechanistic

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Longevity & Mitochondria

Restore NAD+ with NMN/NR, activate sirtuins with Pterostilbene, support mitochondrial biogenesis with CoQ10 + PQQ, and promote autophagy with Spermidine.

Tier 2-3 — Emerging Human Data

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Metabolic Health

Activate Nrf2 pathways with Sulforaphane, monitor glucose response with CGMs, and optimize insulin sensitivity through chrono-exercise timing.

Tier 1-2 — Clinical Data

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Recovery & Resilience

Accelerate recovery with Red Light Therapy (660nm/850nm), deliberate cold exposure (Soeberg Principle), and Creatine Monohydrate for brain + muscle energy.

Tier 1 — Meta-analyses

Frequently Asked Questions

What is biohacking?

Biohacking is the practice of using science, technology, and self-experimentation to optimize biological function. Evidence-based biohacking focuses on interventions supported by peer-reviewed clinical research rather than anecdotal claims.

Are biohacking supplements safe?

Safety depends on the specific supplement, dosage, quality of sourcing, and individual health conditions. Always consult a healthcare professional before starting any supplement protocol. Our Stack Builder includes safety screening for drug interactions and contraindications.

What is the GRADE evidence framework?

GRADE (Grading of Recommendations Assessment, Development and Evaluation) is a systematic approach used in clinical medicine to rate the quality of evidence. Our tool uses a simplified version: Tier 1 (strong RCT evidence), Tier 2 (moderate evidence), and Tier 3 (emerging/preclinical).

How much does a biohacking protocol cost?

A foundation stack (Magnesium, Vitamin D3/K2, Omega-3, Creatine) costs $50-80/month. Adding cognitive enhancers brings it to $100-150/month. Advanced longevity molecules (NMN, Pterostilbene) can push costs above $300/month.

Should I use a CGM if I'm not diabetic?

CGMs are valuable as short-term educational tools (2-4 weeks) to understand your personal glucose response to foods and exercise. However, experts caution against long-term use by healthy individuals due to the risk of "orthorexia" — unhealthy obsession with perfect glucose curves.